plasma concentration vs time profiles  (Gilead Sciences)

Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Article Title: A population pharmacokinetic model of remdesivir and its major metabolites based on published mean values from healthy subjects

doi: 10.1007/s00210-022-02292-6

Figure Lengend Snippet: Simulated plasma concentration‐vs.‐time profiles of remdesivir, GS‐704277, and GS‐441524 following a simulated 30-min intravenous infusion of 200 mg of remdesivir on day 1, with 100 mg, 30-min intravenous infusion for the following 4 days. The bottom part of the remdesivir panel shows the fraction of censored observation numbers to the total observations at a given time. There were no censored observations for the metabolites. Dotted lines reflect standard deviation values

Article Snippet: Fig. 2 Observed mean concentrations (black dots) and model predictions (black line) of each given dose, following single 2-h intravenous infusion of either 3 mg, 10 mg, 30 mg, 75 mg, 150 mg, or 225 mg of remdesivir Fig. 3 Goodness-of-fit plots describing remdesivir model-predicted plasma concentration value agreement with the observed values Population parameter estimates for the mean of the published plasma concentration‐vs.‐time profiles of remdesivir, GS‐704277, and GS‐441524 following remdesivir 2-h single-dose intravenous administration in healthy volunteers are described in detail in Table .

Techniques: Concentration Assay, Standard Deviation